Correction: PDGFRα depletion attenuates glioblastoma stem cells features by modulation of STAT3, RB1 and multiple oncogenic signals
نویسندگان
چکیده
RESULTS Cancer stem cells from GBM were isolated as described previously [24]. We were able to collect either core(c-CSC) or peritumor tissue-derived cancer stem cells (p-CSC) from several primary GBM samples. The two types of CSC form intracranial tumors in immunocompromised mice. Nevertheless, c-CSC showed a higher tumor initiating ability when compared with p-CSC which had a lower tumorigenicity [24]. REFERENCES
منابع مشابه
PDGFRα depletion attenuates glioblastoma stem cells features by modulation of STAT3, RB1 and multiple oncogenic signals
Platelet derived growth factor receptors (PDGFRs) play an important role in tumor pathogenesis, and they are frequently overexpressed in glioblastoma (GBM). Earlier we have shown a higher protein expression of PDGFR isoforms (α and β) in peritumoral-tissue derived cancer stem cells (p-CSC) than in tumor core (c-CSC) of several GBM affected patients. In the current study, in order to assess the ...
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